Patient With COPD-Asthma Overlap Detected by Sputum Eosinophilia

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Characterization of sputum biomarkers for asthma–COPD overlap syndrome

Asthma-COPD overlap syndrome (ACOS) is a commonly encountered chronic airway disease. However, ACOS is still a consensus-based clinical phenotype and the underlying inflammatory mechanisms are inadequately characterized. To clarify the inflammatory mediatypical for ACOS, five biomarkers, namely interleukin (IL)-13, myeloperoxidase (MPO), neutrophil gelatinase-associated lipocalin (NGAL), chitin...

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Characterization of sputum biomarkers for asthma–COPD overlap syndrome [Erratum]

[This corrects the article on p. 2457 in vol. 11, PMID: 27757028.].

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Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma

BACKGROUND Chronic obstructive pulmonary disease (COPD) and asthma may overlap and converge in older people (overlap syndrome). It was hypothesized that patients with overlap syndrome may have different clinical characteristics such as sputum eosinophilia, and better responsiveness to treatment with inhaled corticosteroid (ICS). METHODS Sixty-three patients with stable COPD (forced expiratory...

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Sputum cell count: biomarkers in the differentiation of asthma, COPD and asthma–COPD overlap

INTRODUCTION Cell count in induced sputum is a noninvasive biomarker to assess airway inflammation phenotypes. Accordingly, sputum cell counts are extensively used in the treatment of asthma and COPD. Nevertheless, the clinical application of sputum cell counts in patients with asthma-COPD overlap (ACO) remains elusive. The aim of this study was to investigate sputum cell counts in patients wit...

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Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap.

The pathophysiological features of chronic obstructive pulmonary disease (COPD)-asthma overlap are poorly understood and there has been no study of plasma or sputum biomarkers in overlap patients. In order to clarify the similarity and differences between overlap and COPD or asthma, we have investigated four potential biomarkers of COPD: surfactant protein A (SP-A), soluble receptor for advance...

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ژورنال

عنوان ژورنال: Journal of Medical Cases

سال: 2015

ISSN: 1923-4155,1923-4163

DOI: 10.14740/jmc2348w